PTCA对急性冠脉综合征患者血浆PS和PAI-1活性的影响

目的 :旨在了解急性冠脉综合征患者经皮冠状动脉成形术 (PTCA)治疗后 ,血小板内皮功能及纤溶活性的变化。方法 :18例冠状动脉造影 (CAG)阴性者为阴性对照 ,14例CAG阳性者为阳性对照 ,31例PTCA治疗的急性冠脉综合征患者 ,观察P 选择素 (PS)、纤溶酶原激活剂抑制物 (PAI 1)的动态变化。采用ELISA法测结果。结果 :PTCA组患者术后 10minPS显著高于术前 (P <0 .0 5 ) ,并显著高于同时段的CAG (+)组和CAG(- )组 (P<0 .0 5 )。PTCA组术后 2 4hPS与术前比较无统计学差异 (P >0 .0 5 )。在术前PTCA组与CAG(+)组PAI 1显著高于CAG(- )组 (P <0 .0 1) ,PTCA组术后与术前PAI 1无明显变化 (P >0 .0 5 )。结论 :PTCA中存在血小板的活化和内皮细胞损伤 ,但只是一过性反应 ,很快可以恢复。PTCA对纤溶系统无直接影响

Effects of PTCA on Plasma P-Selectin and Plasminogen Activator Inhibitor-1 in Patients With Acute Coronary Syndrome

Objective: Our aim was to investigate changes of the function of platelet and endothelial cells and the fibrinolytic activity in patients with acute coronary syndrome after percutaneous transtuminal coronary angioplasty(PTCA).Methods:This study included 3 groups: 18 persons with negative results for coronary arteriography(CAG),14 with positive results for CAG , and 31 patients with acute coronary syndrome after PTCA.The ELISA method was used to detect levels of P selectin(PS) and plasminogen activator inhibitor type 1(PAI 1). Results: Ten minutes after PTCA,the plasma level of PS was significantly higher than those of before PTCA,CAG (negative),and CAG(positive) groups(P0.05),while there was no difference between 24 hours after PTCA and before PTCA(P>0.05). The plasma levels of PAI 1 before PTCA in PTCA group and CAG positive group were significantly higher than that of CAG negative group(P<0.01), and there was no difference between before PTCA and after PTCA (P>0.05). Conclusion: The activation of platelet and injury of endothelial cells are unavoidable during PTCA, and it is temporary and would recover quickly. The PTCA has no direct effect on fibrinolytic system.