Effect of increased intracranial pressure on gastric acid secretion |
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| Authors: | S J Mulvihill T N Pappas H T Debas |
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| Affiliation: | 1. Department of Endocrinology and Metabolism, Transgender Clinic, Peking University Third Hospital, Beijing, China;2. Transgender Division, Beijing LGBT Center, Beijing, China;3. Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China;4. Department of Plastic Surgery, Transgender Clinic, Peking University Third Hospital, Beijing, China;5. Department of Psychiatry, University of British Columbia, Vancouver, Canada;1. Department of Clinical Nursing, University College Hospital Ibadan, Nigeria;2. Department of Nursing, University of Ibadan, Ibadan Nigeria;3. Department of Nursing, University of Maiduguri, Maiduguri Nigeria;1. Division of Cardiothoracic Surgery, Department of Surgery, New York Presbyterian/Morgan Stanley Children''s Hospital, Columbia University Irving Medical Center, New York, NY;2. Division of Pediatric Cardiology, Department of Pediatrics, New York Presbyterian/Morgan Stanley Children''s Hospital, Columbia University Irving Medical Center, New York, NY;3. Division of Reproductive Science, Department of Ob/Gyn and Department of Surgery, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY;4. Division of Plastic Surgery, Department of Surgery, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY;5. Now with Division of Cardiothoracic Surgery, Department of Surgery, Children''s Healthcare of Atlanta and Emory University, Atlanta, Ga |
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| Abstract: | The effects of intracranial pressure on gastric acid secretion were studied in 30 rabbits. Intracranial pressure was increased in a graded and controlled fashion using a barostat connected to a cannula in the lateral cerebral ventricle. Eighteen rabbits were studied under urethane anesthesia with a background subthreshold intravenous infusion of bethanechol. Twelve rabbits were studied in the conscious state. Increases in intracranial pressure led to immediate and significant increases in gastric acid output in a dose-related manner in both conscious and anesthetized animals. Serum gastrin levels did not increase in either group of animals. Vagotomy only partially abolished the increase in acid outputs seen with increased intracranial pressure, whereas atropine completely blocked the response. We conclude that increased intracranial pressure causes stimulation of acid secretion by a gastrin-independent cholinergic mechanism that is only partially mediated by the vagus. |
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