原发性鼻腔鼻窦恶性黑色素瘤八例临床分析

目的：探讨原发性鼻腔、鼻窦恶性黑色素瘤的诊断和治疗方法。方法：对8例该类患者的临床资料进行回顾性分析。结果：病理形态以多种细胞类型和组织形态混合存在为主要特点，无色素型黑色素瘤S－100蛋白均阳性。所有患者均得到手术治疗且切缘阴性。术后加放疗6例，复发3例，复发灶与原发病灶同侧，复发时间在术后1年左右。1年和2年生存率分别为75％和62％。2例生存期超过5年，均系手术加放疗者。结论：S－100蛋白是无色素型黑色素瘤的重要标志物，术后放疗的患者生存期较长，手术切缘阴性并不提示良好的预后。

Clinical Analysis of Eight Cases with Primary Malignant Melanoma in Nasal Cavity and Paranasal Sinuses

Purpose: To investigate the methods of both diagnosis and treatment for primary malignant melanoma in nasal cavity andparanasal sinuses. Method: Eight cases were analysed retrospectively. Results: The pathological features were the mixed existance of dif-ferent cellular patterns and morphologies. There was S-100 protein marking for malignant melanoma. All patients underwent surgicalresection and microscopically negative margins,with six receiving postoperative radiotherapy. Three cases recurred at the same side asprimary tumor about one year Iater. The 1 -year and 2-year survival rate in all were 75 % and 62 % respectively. Two cases had sur-vived more than five years who all received postoperative radiotherapy. Conclusion: S-100 protein was an important diagnostic marker formalignant melanoma. Those who received postoperative radiotherapy appeared with prolonged survival. Negative surgical margins werenot predictive of a more favorable outcome.