共轭亚油酸强化乳对小鼠体脂及血脂的影响

目的:探讨共轭亚油酸(CLA)强化乳对小鼠体脂及血脂的影响。方法:选4w龄的雄性昆明种小鼠40只,随机分成四组,每组10只,分别在牛奶中添加0%、0.1%、0.5%、1.0%的CLA喂养小鼠4w后,测定体重、腹脂重、体脂含量、饲料利用率及血浆甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇含量(HDL)与脂蛋白脂酶(LPL)活性。结果:小鼠的体增重、腹脂重、体脂含量及饲料利用率都随着乳中CLA的添加量增加而降低,与对照组比,当添加0.5%时达到显著差异;在乳中添加CLA可以降低小鼠血浆中的TG与TC含量,提高HDL含量和LPL活性,降低动脉硬化指数(TC-HDL/HDL)。TC含量在添加0.5%CLA时最低,其它的血脂指标在添加1.0%CLA时效果最好。结论:共轭亚油酸强化乳有降低体脂和血脂的作用。

EFFECT OF FORTIFIED CONJUGATED LINOLEIC ACID MILK ON BODY FAT AND PLASMA LIPIDS IN MICE

Objective: To study the effects of fortified conjugated linoleic acid (CLA) milk on body fat and plasma lipids in mice.Method:Forty male Kunming mice of 4 w old were randomly divided into four groups and fed diet and milk supplemented with 0%,0.1%,0.5%,1.0% CLA (percent of diet, dry mass) respectively for 4 w.Weight gain,body fat,intra-abdominal fat,feed conversion efficiency and plasma TG, TC, HDL , LPL were measured.Results:At the end of the experiment, all these physiological indices were decreased with increasing CLA in the milk and were lower significantly than that of control group when supplemented with 0.5% CLA in milk. TG , TC and (TC- HDL) / HDL were decreased, but HDL and LPL were increased with increasing CLA amount in the milk. TG,HDL,LPL and (TC- HDL)/ HDL were best when fed the milk supplemented with 1.0% CLA,while TC was the lowest when fed the milk supplemented with 0.5% CLA . Conclusion:The fortified conjugated linoleic acid is effective in lowering body fat and blood lipids.