碱性成纤维细胞生长因子滴眼液在单纯疱疹性角膜炎中的应用

目的 探讨碱性成纤维细胞生长因子滴眼液治疗单纯疱疹性角膜炎的临床疗效.方法 选取我院就诊的42例单纯疱疹性角膜炎患者,随机均分为对照组和实验组,对照组患者用更昔洛韦眼用凝胶联合无环鸟苷滴眼液进行治疗,实验组患者用更昔洛韦眼用凝胶联合碱性成纤维细胞生长因子滴眼液进行治疗.比较两组患者治疗痊愈率和总有效率、角膜溃疡改善情况及不良反应发生率的差异.结果 实验组患者痊愈率和总有效率分别为66.7％和90.5％,均显著高于对照组的28.6％和61.9％ （P＜0.05）;实验组角膜溃疡改善情况显著优于对照组（P＜ 0.05）;两组患者均无不良反应发生（P＞0.05）.结论 用更昔洛韦眼用凝胶联合碱性成纤维细胞生长因子滴眼液治疗单纯疱疹性角膜炎疗效确切,见效快,无不良反应.

Eye drops of basic fibroblast growth factor for herpes simplex keratitis

Objective To investigate the efficacy of eye drops of basic fibroblast growth factor in the treatment of herpes simplex keratitis.Methods 42 patients with herpes simplex keratitis from our hospital were randomly divided into a control group receiving ganciclovir ophthalmic gel combined with acyclovir eye drops and an experimental group receiving ganciclovir ophthalmic gel combined with eye drops of basic fibroblast growth factor.The cure rate,total effective rate,improvement of corneal ulcers,and adverse reactions rate of the two groups were compared.Results The cure rate and total effective rate of the experimental group were 66.7％ and 90.5％,respectively,which were significantly higher than that of the control group （28.6％ and 61.9％） （P ＜ 0.05）.The improvement of corneal ulcers were better in the experimental group than in the control group（P ＜ 0.05）.No adverse reaction occurred in both groups （P ＞ 0.05）.Conclusions Ganciclovir ophthalmic gel combined with eye drops of basic fibroblast growth factor for herpes simplex keratitis is effective and has rapid onset and no adverse reaction.