吸入布地奈德／福莫特罗和布地奈德／沙丁胺醇对哮喘急性发作儿童支气管扩张的效果探讨

目的比较吸入布地奈德（100μg）／福莫特罗（6μg）、布地奈德（100μg）／沙丁胺醇（100μg）组合在5—15岁儿童哮喘发作期对支气管扩张的效果。方法采用双盲随机对照试验，研究组给予使用布地奈德100μg＋福莫特罗6μg组合压力式定量气雾装置吸入（MDI），对照组给予布地奈德100μg＋沙丁胺醇100μg组合MDI。所有的儿童接受三次剂量的药物，给药间隔时间在20分钟以内。分析比较FEV1（％预计值）以及修正的肺指标值（MPIS），研究两组在1、5、15、30、60分钟后的药效。结果干预后两组之间1、5、15、30、60分钟FEV1（％预计值）的比较差异无统计学意义（P〉0．05）。而对照组、研究组自身的（FEV1％预计值）绝对变化值，从基线到60分钟的差值为（12．2±2．5）以及（9．4±2．0），两组比较差异有统计学意义（t=3．50，P〈0．05）。在两组基线相比，1、5、15、30、50分钟，从基线FEV1百分比变化也相似。呼气峰流速（PEFR），百分比预测PEFR，用力呼气流速50（FEF50）和百分比预测FEF50，在两组相似研究过程中不同时间点也相似。其他肺功能参数两组之间比较差异无统计学意义。结论沙丁胺醇或福莫特罗，在二定吸入剂量的作用下，对轻度哮喘急性发作期5～15岁之间的儿童，有类似的支气管扩张作用。

Bronchodilatation effect of inhaled budesonide/formoterol and budesonide/salbutamol in treating children with acute asthma

Objective To compare bronchodilation effects of inhaled budesonide/formoterol （dose： 100 μ g and 6μ g） and budesonide （100 μ g）/salbutamol （100 μ g） for the 5-15 year-old children with asthma exacerbation. Methods A double-blind randomized controlled trial was conducted each MDI intervals, children were administered two times, receiving formoterol or salbutamol, both groups received 100 μg of budesonide. At 20-minute intervals, all children received three doses of the drug. Analysis and comparison of FEV 1 （% predicted） and the amendments to the pulmonary index score （MPIS） were analyzed. Efficacies of 1,5,15,30,60 minutes were studied. Results FEVI（% predicted） and MPIS had no significant differences. From 1 minute to 60 minutes, one minute after administration, FEV1 （% predicted）, formoterol and salbutamol from baseline were significantly improved. Peak expiratory flow rate （PEFR）, percentage of predicted PEFR, forced expiratory flow 50 （FEF50） and percentage of predicted FEF50 were significantly improved. At different time points, the two groups were similar during the study and were not statistically significant. Conclusions In a certain inhaled dose, mild acute asthma among 5-15 years children, salbutamol or formoterol have a similar bronchodilator effect.