The levels of blood mercury and inflammatory-related neuropeptides in the serum are correlated in children with autism spectrum disorder |
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| Authors: | Gehan Ahmed Mostafa,Geir Bjørklund author-information" >,Mauricio A. Urbina,Laila Yousef AL-Ayadhi |
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| Affiliation: | 1.Department of Pediatrics, Faculty of Medicine,Ain Shams University,Cairo,Egypt;2.Autism Research and Treatment Center, AL-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine,King Saud University,Riyadh,Saudi Arabia;3.Council for Nutritional and Environmental Medicine,Mo i Rana,Norway;4.Department of Biosciences, College of Life and Environmental Sciences,University of Exeter,Exeter,UK;5.Departamento de Zoología, Facultad de Ciencias Naturales y Oceanográficas,Universidad de Concepción,Concepción,Chile |
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| Abstract: | Tachykinins (substance P, neurokinin A, and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory diseases, including autism spectrum disorder (ASD). Mercury (Hg) is a neurotoxicant, and potentially one of the main environmental triggers for ASD as it induces neuroinflammation with a subsequent release of neuropeptides. This is the first study to explore the potentially causal relationship between levels of serum neurokinin A and blood mercury (BHg) in children with ASD. Levels of serum neurokinin A and BHg were measured in 84 children with ASD, aged between 3 and 10 years, and 84 healthy-matched children. There was a positive linear relationship between the Childhood Autism Rating Scale (CARS) and both serum neurokinin A and BHg. ASD children had significantly higher levels of serum neurokinin A than healthy controls (P?P?
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