The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: A cohort study of 95 patients with autoimmune thyroid disorders |
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Authors: | Eliska Potlukova Jan Jiskra Tomas Freiberger Zdenka Limanova Dana Zivorova Karin Malickova Drahomira Springer Lucie Grodecka Marie Antosova Zdenek Telicka Satu Sinikka Pesickova Marten Trendelenburg |
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Institution: | 1. Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic;2. Centre for Cardiovascular Surgery and Transplantation, Molecular Genetics Laboratory, Brno, Czech Republic;3. Institute of Clinical Biochemistry and Laboratory Diagnostics, Laboratory of Clinical Allergology and Immunology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic;4. Clinic of Nephrology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic;5. Laboratory of Clinical Immunology, Department of Biomedicine, University Hospital Basel, Switzerland |
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Abstract: | Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD). Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype. |
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Keywords: | Mannan-binding lectin Complement Autoimmune thyroid disorders Graves' disease Hashimoto's thyroiditis |
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