基于代谢组学的干细胞研究进展 |
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引用本文: | 施宇光,金茜,赵冬梅,李兴库,于景翠,王宜淳,刘伟. 基于代谢组学的干细胞研究进展[J]. 国际遗传学杂志, 2016, 0(1): 27-30. DOI: 10.3760/cma.j.issn.1673-4386.2016.01.005 |
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作者姓名: | 施宇光 金茜 赵冬梅 李兴库 于景翠 王宜淳 刘伟 |
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作者单位: | 1. 哈尔滨医科大学附属第二医院科研实验中心,150081;2. 大连枫叶国际学校,116000;3. 哈尔滨医科大学心肌缺血教育部重点实验室,150081 |
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基金项目: | 黑龙江省自然科学基金,哈尔滨医科大学心肌缺血省部共建重点实验室开放课题 |
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摘 要: | 代谢组学是一种定性和定量分析复杂生物样品中所有小分子代谢物的组学方法,主要考察生物体系受刺激或扰动后内源性代谢物的变化,是系统生物学的重要组成部分.近年来代谢组学在评判细胞功能状态及决定细胞命运的代谢途径的研究中取得了很大的进展.干细胞治疗作为一种再生医学,为各种退行性疾病的治疗带来了新的希望,成为目前的研究热点,本文重点综述了代谢组学在分析各种干细胞研究中的进展.
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关 键 词: | 代谢组学 干细胞 临床应用 |
Research progress in stem cells based on the metabonomics |
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Abstract: | Metabonomics is now widely applied to analyze all the small molecule metabolites in complex biological samples quantitatively and qualitatively,and to investigate the changes in endogenous metabolites of organisms after stimulus or disturbance.Recently,studies on metabonomics,functioning as an important part of system biology,have achieved considerable progress in evaluating the functional status of cells or the specific metabolic pathways in dictating cell fate.With rapid advances in understanding of the promising roles of stem cells therapy,as apart of regenerative medicine in various degenerative diseases,metabonomics becomes a hot research topic now.In this article,we mainly review the progress of metabonomics in analyzing clinical application of various stem cells |
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Keywords: | Metabolomics Stem cells Clinical application |
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