CD147和EGFR蛋白表达与胃癌转移和预后的关系

目的 探讨细胞外基质金属蛋白酶诱导因子CD147和表皮生长因子受体(EGFR)的表达与胃癌临床病理特征和患者预后的关系.方法 应用免疫组织化学法检测63例胃癌和40例癌旁正常组织中CD147和EGFR蛋白表达,并结合肿瘤的病理学行为和临床随访资料进行分析.结果 在胃癌组织中CD147和EGFR阳性表达率分别为77.8％ (49/63)和42.9％(27/63),均显著高于癌旁正常组织的25.0％和0(x2 =27.851,P =0.000;x2=23.233,P=0.000).在胃癌组织中,CD147和EGFR表达与肿瘤浸润深度(x2=5.992,P=0.014;x2=13.148,P =0.000)、TNM分期(x2=8.481,P=0.004;x2=14.589,P=0.000)、淋巴结转移(x2=5.270,P=0.022;x2 =20.261,P =0.000)和患者预后(x2=5.606,P =0.018;x2 =4.982,P=0.026)密切相关;CD147表达还与Ki-67增殖指数(x2=10.481,P=0.001)相关.CD147与EGFR的表达呈正相关(r=0.309,P=0.014).结论 CD147和EGFR表达与胃癌发生、转移和患者生存期密切相关,检测CD147和EGFR蛋白表达可作为判断胃癌预后的参考指标.

Expressions of CD147 and EGFR protein and their relationship with metastasis and prognosis of gastric cancer

Objective To investigate the expressions of extracellular matrix metalloproteinase inducer molecule CD147 and epidermal growth factor receptor (EGFR) protein in gastric cancer and their relationship with the pathological behavior and prognosis.Methods Immunohistochemical staining was used to detect the expressions of CD147 and EGFR protein in 63 cases of gastric cancer and 40 cases of paracancerous normal tissues.The study was also combined with analysis of the pathological behavior and clinical follow-up survey of gastric cancer.Results The positive expression rates of CD147 and EGFR protein in gastric cancer were 77.8％ (49/63) and 42.9％ (27/63),respectively,which were higher than those in paracancerous normal tissues 25.0％ and 0 (x2 =27.851,P =0.000;x2 =23.233,P =0.000).In gastric cancer,the expressions of CD147 and EGFR were closely related to the depth invasion (x2 =5.992,P =0.014;x2 =13.148,P =0.000),TNM stages (.x2 =8.481,P=0.004;x2=14.589,P=0.000),lymph node metastasis (x2 =5.270,P=0.022;x2=20.261,P =0.000) and prognosis of patients (x2 =5.606,P =0.018;x2 =4.982,P =0.026).The expression of CD147 was also significantly correlated with Ki-67 expression (x2 =10.481,P =0.001).CD147 expression was positively correlated with EGFR expression(r =0.309,P =0.014).Conclusion The expressions of CD147 and EGFR are closely related to carcinogenesis,metastasis and survival time of gastric cancer.Detecting the expressions of CD147 and EGFR may be prognostic indicators of gastric cancer.