Vitamin D deficiency is associated with acute ischemic stroke,C-reactive protein,and short-term outcome

The aim of this study was to investigate whether vitamin D deficiency (VDD) is associated with acute ischemic stroke, inflammatory markers, and short-term outcome. 168 acute ischemic stroke patients and 118 controls were included. The modified Rankin Scale (mRS) was applied up to 8 h of admission (baseline) and after three-months follow-up, and blood samples were obtained up to 24 h of admission to evaluate serum levels of 25-hydroxivitamin D [25(OH)D] and inflammatory markers. Vitamin D levels classified the individuals in sufficient (VDS?≥?30.0 ng/mL), insufficient (VDI 20.0–29.9 ng/mL), and deficient (VDD?p?p?p?=?0.043); those with poor outcome presented with lower 25(OH)D levels than those with good outcome (p?=?0.008); moreover, 25(OH)D levels were negatively correlated with mRS after three-months follow-up (r?=??0.239, p?=?0.005). The associations between VDD and higher hsCRP levels and between 25(OH)D levels and poor outcome at short-term in acute ischemic stroke patients suggest the important role of vitamin D in the inflammatory response and pathophysiology of this ischemic event.