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The influence of cytoreductive surgery on the response to chemotherapy of a rat renal cancer |
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| Authors: | R deVere White A D Deitch W -K Hong C A Olsson |
| Institution: | (1) Department of Urology, Columbia University College of Physicians and Surgeons, New York, New York, USA;(2) the Section of Medical Oncology, Boston, Veterans Administration Medical Center, Boston, Massachusetts, USA;(3) Department of Urology, University of California School of Medicine, Davis, California, USA |
| Abstract: | Summary The potential ability of cytoreductive surgery to increase the effectiveness of chemotherapy (vindesine) was tested utilizing male Wistar Lewis rats transplanted simulataneously with intraperitoneal and flank implants of a spontaneously arising renal adenocarcinoma. Cytoreduction was accomplished in some animals by removing the flank tumor 5–7 weeks following implantation; all animals received vindesine (IP injection of 0.5 mg/kg on two successive weeks). While vindesine reduced tumor growth, in no case did the addition of cytoreductive surgery enhance the effect of chemotherapy. The addition of cytoreductive surgery to marginally effective chemotherapy was found to be ineffective or even detrimental.Abbreviations VDR vindesine - IP intraperitoneal |
| Keywords: | Cytoreductive surgery Chemotherapy Renal adenocarcinoma Rats |
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