Immunoglobulin-containing cells in the colonic mucosa of rabbits with carrageenan-induced colitis |
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| Authors: | Dr. Takayuki Matsumoto M.D. Atsuo Kitano M.D. Nobuhide Oshitani M.D. Akishige Obata M.D. Masato Hiki M.D. Hidechika Hashimura M.D. Kiyotaka Okawa M.D. Hiroshi Nagura M.D. Kenzo Kobayashi M.D. |
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| Affiliation: | (1) Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahimachi, Abeno-ku, 545 Osaka, Japan;(2) Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Osaka, Japan |
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| Abstract: | Immunohistochemical analysis of immunocompetent cells in the colonic mucosa was performed with carrageenan-induced experimental colitis in rabbits. Colitis was induced by seven months of oral administration of λ-degraded carrageenan following immunization with the same substances containing Freund's complete adjuvant. In the colonic mucosa with colitis, IgG- and IgM-containing cells were significantly increased in number (IgG: 540±94/mm2 in experimental group,vs. 120±54/mm2 in control,P<.05, IgM: 55.0±19.7/mm2 in experimental group,vs. 6.7±2.4/mm2 in control,P<.05). There was no significant increase of IgA-containing cells either in number or in proportion to the total mononuclear cells. These changes, induced by carrageenan in rabbits, had resembled those in human ulcerative colitis well. These observations suggested an impairment of the IgA-regualted local immune system and an abnormality in the differentiation process of immunoglobulin-secreting cells. Supported in part by Japanese Ministry of Public Welfare grant (research group on disturbance of digestion and absorption). |
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| Keywords: | Immunoglobulin-containing cell Experimental colitis Carrageenan Colonic mucosa Immunohistochemistry |
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