多囊卵巢综合征的炎症机制及中药干预进展

多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是一种常见,异质,复杂的内分泌疾病。胰岛素抵抗与高雄激素血症是多囊卵巢综合征发病的两大核心病理基础,但确切机制尚未清楚。近年来大量研究证据表明,PCOS患者体内存在低度炎症,而体内低度炎症状态又能诱发的高雄激素导致代谢异常,增加胰岛素抵抗的产生诱导及加重PCOS。中医认为痰瘀互结是低度炎症的基本病理特征,中医药的干预治疗有助于改善PCOS体内低度炎症状态。本文将从PCOS的炎症机制及中医药干预对其的影响作一综述,以期为PCOS的机制研究拓展新的思路,为中医药的干预治疗提供基础理论依据。

Inflammation Mechanism of Polycystic Ovary Syndrome and TCM Intervention in Progress

Polycystic ovarian syndrome(PCOS)is a common,heterogeneous and complex endocrine disease.Insulin resistance and hyperandrogenemia are the two core pathological foundations of the pathogenesis of polycystic ovary syndrome,but the exact mechanism is not yet clear.In recent years,a large amount of research evidence shows that there is low-grade inflammation in patients with PCOS,and the high-androgen that can be induced by the low-grade inflammatory state in the body leads to metabolic abnormalities,increases the induction of insulin resistance and worsens PCOS.Traditional Chinese medicine believes that phlegm and blood stasis are the basic pathological features of low-grade inflammation,and the intervention of Chinese medicine helps to improve the low-grade inflammatory state of PCOS.This article will review the inflammatory mechanism of PCOS and the impact of traditional Chinese medicine intervention on it,with a view to expanding new ideas for the research of the mechanism of PCOS and providing basic theoretical basis for the intervention treatment of traditional Chinese medicine.