| 牙周炎症微环境对牙龈上皮屏障影响研究进展 |
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| 引用本文： | 王佳岱,张璇,林莉. 牙周炎症微环境对牙龈上皮屏障影响研究进展[J]. 中国实用口腔科杂志, 2021, 14(2): 229-233. DOI: 10.19538/j.kq.2021.02.021 |
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| 作者姓名： | 王佳岱 张璇 林莉 |
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| 作者单位： | 中国医科大学口腔医学院·附属口腔医院牙周病科，辽宁 沈阳 110002 |
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| 基金项目： | 国家自然科学基金(81970942);辽宁省教育厅科学研究项目(JC2019024)。 |
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| 摘 要： | 牙周病是一种常见的慢性炎症性疾病,与牙周致病菌、黏膜和免疫宿主细胞之间复杂的相互作用有关.牙龈卟啉单胞菌(Porphyromonas gingivalis,P.gingivalis)在牙周病中被认为是重要的致病菌之一,与黏膜和免疫细胞相互作用,导致炎症细胞因子的产生.牙龈上皮是口腔微生物群的物理和免疫屏障,在牙周组织感...
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| 关 键 词： | 炎症微环境 牙龈上皮屏障 牙龈卟啉单胞菌 |
Research progress in the influence of periodontal inflammation microenvironment on gingival epithelial barrier |
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| WANG Jia-dai,ZHANG Xuan,LIN Li. Research progress in the influence of periodontal inflammation microenvironment on gingival epithelial barrier[J]. chinese Journal of Practical Stomatology, 2021, 14(2): 229-233. DOI: 10.19538/j.kq.2021.02.021 |
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| Authors: | WANG Jia-dai ZHANG Xuan LIN Li |
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| Affiliation: | (Department of Periodontology,School and Hospital of Stomatology,China Medical University,Shenyang 110002,China) |
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| Abstract: | Periodontal disease is a common chronic inflammatory disease，which is related to the complex interaction among periodontal bacteria，mucosa and immune host cells. Porphyromonas gingivalis（P. gingivalis）is considered as one of the important pathogenic bacteria in periodontal disease，which interacts with mucous membranes and immune cells and leads to the production of inflammatory cytokines. Gingival epithelium is the physical and immune barrier of oral microflora，which plays a vital role in activating immune response after periodontal tissue infection and inflammation. This article reviews the researches in the response of gingival epithelial cells in the inflammatory microenvironment stimulated by P. gingivalis. |
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| Keywords: | inflammatory microenvironment；gingival epithelial barrier；Porphyromonas gingivalis P.gingivalis |
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