Abstract: | Objective To analyze the distribution and antimicrobial resistance of pathogens isolated from patients with stroke-associated pneumonia (SAP) between the respiratory department and intensive care unit(ICU) in our hospital, so as to provide references for rational use of antimicrobial agents. Methods A retrospective study was conducted by analyzing antimicrobial resistance of SAP between the respiratory department and ICU in our hospital from January 2016 to June 2019, and investigating the proportion of ESBLs-producing and carbapenem resistant organisms. Results A total of 41 clinical isolates were collected from the respiratory department. Among them, Gram-negative bacilli and Gram-positive cocci accounted for 92.67% and 7.32%. The three most isolated pathogens were Klebsiella pneumoniae (n=16, 39.02%), Pseudomonas aeruginosa (n=7, 17.07%), and Acinetobacter baumannii (n=6, 14.63%). Meanwhile, 137 clinical isolates were collected from ICU. Among them, Gram-negative bacilli and gram-positive cocci accounted for 93.43% and 6.57% respectively. The three most isolated pathogens were Klebsiella pneumoniae (n=43, 31.39%), Acinetobacter baumannii (n=38, 27.74%), and Pseudomonas aeruginosa (n=16, 11.68%). In the respiratory department, the proportion of ESBLs-producing Klebsiella pneumoniae and carbapenem resistant Klebsiella pneumoniae were 50% and 12.5%, while it was 41.86% and 2.33% respectively in ICU. In the respiratory department, the proportion of carbapenem resistant Acinetobacter baumannii and carbapenem resistant Pseudomonas aeruginosa were 66.67% and 28.57% respectively while it were 97.37% and 37.5% in ICU. The resistance of Acinetobacter baumannii to carbapenem in ICU was significantly higher than in respiratory department (P<0.05). Conclusion The major pathogens causing SAP in respiratory department and ICU were all Gram-negative bacilli. Most of them were resistant to carbapenem. Meanwhile, Klebsiella pneumoniae became the most frequent pathogen. Even CRKP was detected which should be paid close attention to. Therefore, it's necessary to enhance monitoring the distribution and antimicrobial resistance of SAP, to provide local etiological data for guiding clinical anti-infection |