不同剂量安宫牛黄丸对急性脑梗死伴中、重度意识障碍痰热内闭证促觉醒作用观察

目的:观察应用不同剂量安宫牛黄丸治疗急性脑梗死伴中、重度意识障碍(痰热内闭证)患者的促觉醒疗效。方法:将急性脑梗死伴中、重度意识障碍(痰热内闭证)患者90例随机分为对照组、观察组1和观察组2。对照组采用常规治疗,观察组1在常规治疗基础上每天加用安宫牛黄一丸,观察组2在常规治疗基础上每天加用安宫牛黄丸两丸。治疗后观察3组治疗后第5及第10天GCS评分,CRP浓度及不良反应。结果:治疗第5天后,对照组GCS评分及CRP浓度与观察组1、观察组2比较,均P<0.05,提示应用安宫牛黄丸治疗5d,其促醒疗效及抗炎作用已经开始显示出来。但观察组1的GCS评分与观察组2比较,P>0.05;观察组1的CRP水平与观察组2比较,P<0.05;提示治疗5d,不同剂量安宫牛黄丸的促醒疗效相当,但“1丸/次,2次/d”的抗炎作用更明显。治疗第10天,对照组GCS评分及CRP浓度与观察组1、观察组2比较,均P<0.05,提示治疗10d后,安宫牛黄丸的抗炎作用及促醒疗效确切;观察组1的GCS评分及CRP浓度与观察组2比较,均P<0.05,提示观察组2的抗炎作用及促觉醒疗效更佳。治疗过程中未发现不良反应。结论:对于急性脑梗死中、重度意识障碍(痰热内闭证)患者,应用安宫牛黄丸治疗,其促觉醒疗效确切,“1丸/次,2次/d”的抗炎作用更强,促觉醒疗效更佳,安全性好。

Effect of Different Doses of Angong Niuhuang Pill on Arousal in Patients with Acute Cerebral Infarction

Objective:To observe the application of different doses of Angong Niuhuang Pill in the treatment of acute cerebral infarction with moderate to severe disturbance of consciousness(heat syndrome).Methods:90 patients with acute cerebral infarction with moderate or severe disturbance of consciousness(heat syndrome)were randomly divided into control group,observation group 1 and observation group 2.The control group received conventional treatment.Observation group 1 Angong Niuhuang Yiwan was added daily on the basis of conventional treatment.Observation group 2 Angong Niuhuang Wan two pills were added daily on the basis of conventional treatment.After treatment,the GCS score,CRP concentration and adverse reactions were observed on the 5th and 10th day after treatment in the 3 groups.Results:After the fifth day of treatment,the CRP score of the control group was higher than that of the obser vation group,and the GCS was lower than that of the observation group 2(P<0.05).It is suggested that the application of Angong Niuhuang Pill for 5 days,its awakening effect and anti-inflammatory effect have begun to show.There were no differences between groups 1 and 2(P>0.05).Prompt treatment for five days,different doses of Angong Niuhuang Pills are equally effective.On the 10th day of treatment,the CRP score of the control group was higher than that of the observation group,and the GCS was lower than that of the observation group 2(P<0.05).It is suggested that the application of Angong Niuhuang Pill can be used for 5 days,and its curative effect and anti-inflammatory effect are exact.Observation group 2 was superior to observation group 1(P>0.05).It is suggested that the anti-inflammatory effect and the wake-awakening effect of observation group 2 are better.No adverse reactions were found during the treatment.Conclusion:For patients with acute cerebral infarction and severe dysfunction disorder(another syndrome),the application of Angong Niuhuang Pill is effective in promoting arousal.The anti-inflammatory effect of“1 pill/time,2 times/d”is stronger.The effect is better and the safety is good.