SARS-CoV、MERS-CoV、SARS-CoV-2的基因结构特点与致病机制

高致病性冠状病毒具有高发病率、高病死率以及全球大流行等特点，严重威胁人类健康，给社会经济带来巨大挑战。目前关于高致病冠状病毒的致病机制，主要从直接细胞病变效应和间接免疫病理损伤两方面进行讨论，但具体作用基因的研究尚需进一步深入。本文从高致病性冠状病毒的基因结构特点与致病机制的相关性进行综述，为预防和治疗高致病性冠状病毒感染提供参考。

Gene structure characteristics and pathogenic mechanism of SARS-CoV,MERS-CoV and SARS-CoV-2

Highly pathogenic coronavirus(HPC) is characterized by high incidence, high mortality and global pandemic, it seriously threatens human health and poses great challenge to social economy. At present, the pathogenic mechanism of HPC is mainly discussed from two aspects:the direct cytopathic effect and indirect immunopathological damage, but the study of specific acting genes still needs further in-depth research. In this paper, the relationship between gene structure characteristics and pathogenic mechanism of HPC is reviewed, so as to provide refe-rence for the prevention and treatment of HPC infection.