|
|||||
|
|
Geographic variations of predominantly hepatitis C virus associated male hepatocellular carcinoma townships in Taiwan: identification of potential high HCV endemic areas |
|
| Authors: | Wei-Wen Su Chien-Hung Chen Hans Hsienhong Lin Sheng-Shun Yang Ting-Tsung Chang Ken-Sheng Cheng Jaw-Ching Wu Shun-Sheng Wu Chuan-Mo Lee Chi-Sin Changchien Chien-Jen Chen Jin-Chuan Sheu Ding-Shinn Chen Sheng-Nan Lu |
| Affiliation: | 1. Department of Internal Medicine, Changhua Christian Hospital, No. 135 Nanxiao, Changhua, Taiwan 2. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, No. 7 Chung San South Rd, Taipei, Taiwan 3. Department of Gastroenterology, Buddhist Tzu Chi General Hospital, No. 707, Sec. 3, Chung Yang Rd, Hualien, Taiwan 4. Department of Internal Medicine, Taichung Veterans General Hospital, No. 160, Sec. 3, Chung-Kang Rd, Taichung, Taiwan 5. Department of Internal Medicine, National Cheng Kung University Hospital, No. 138, Sheng Li Rd, Tainan, Taiwan 6. Division of Gastroenterology, Department of Internal Medicine, China Medical University Hospital, No. 2 Yuh-Der Rd, Taichung City, Taiwan 7. Institute of Clinical Medicine, National Yang-Ming University School of Medicine, No. 155, Sec. 2, Li-Nong St, Pei-Tou, Taipei, Taiwan 8. Department of Medical Research Education, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Rd, Taipei, Taiwan 10. School of Medicine, Chang Gung University College of Medicine, 259 Wen-Hwa 1st Rd, Kwei-Shan Taoyuan, Taiwan 9. Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, 123 Tapi Rd, Niaosung Kaohsiung, Taiwan 11. Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd, Taipei, Taiwan 12. Hepatitis Research Center, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan |
| Abstract: | PurposeThe proportion of B-HCC cases in Taiwan has progressively decreased over the last 20 years. It was not really due to an overall decrease in B-HCC but due to an increase in HCV-related HCC. The identification of potential HCV endemic areas in Taiwan has consequently become important.MethodsData were collected retrospectively from eight Taiwan medical centers from 1981 to 2001, the geographical variations of male C-HCC townships in Taiwan were illustrated on maps. Goodness of fit was used to compare the anti-HCV prevalence in townships and cities, with the mean anti-HCV prevalence for Taiwan as a whole. Township-, city-, and county-specific prevalence of anti-HCV was presented as the median, ranges, and SMRs.ResultsGeographic variation can be analyzed in only 263 townships and cities. The maps were designed on the basis of different SMRs. The mean anti-HCV prevalence for male HCC patients in Taiwan was 31.9% (95% confidence interval: 30.7–33.0). Twenty-five townships distributed throughout central-western and south-western Taiwan have significantly higher prevalence (P < 0.05) (12 townships SMR ≥ 2; 13 townships 1.5 ≤ SMR < 2). Twenty-two townships have significantly lower prevalence (P < 0.05) (6 townships 0.5 ≤ SMR<1; 16 townships SMR < 0.5). Four different patterns of geographic variation in different counties were also noted and demonstrated.ConclusionWe successfully highlighted some potential high HCV endemic townships in Taiwan. |
| Keywords: | Hepatocellular carcinoma Hepatitis B virus Hepatitis C virus Geographic variation Taiwan |
| 本文献已被 SpringerLink 等数据库收录！ | |