Correlates of Metabolic Abnormalities in Bipolar I Disorder at Initiation of Acute Phase Treatment |
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Authors: | Byungsu Kim Sangeok Kim Roger S McIntyre Hui Joon Park Seong Yoon Kim and Yeon Ho Joo |
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Institution: | 1.Department of Psychiatry and Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.;2.Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.;3.Department of Psychiatry, University of Toronto, and the Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Ontario, Canada.;4.Department of Psychiatry, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. |
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Abstract: | ObjectiveTreatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar I patients, at the time of commencement of pharmacological treatment for acute mood episodes.MethodsThe study cohort consisted of 184 bipolar I patients hospitalized for treatment of acute mood episodes. Socio-demographic and clinical variables were noted and metabolic parameters, including body mass index, fasting plasma glucose, fasting total cholesterol, and current treatment(s) for diabetes and/or dyslipidemia were measured before initiating medication(s).ResultsFifty-six (30.4%) subjects met our criteria for obesity; 80 (43.5%) had hyperglycemia, with 8 (4.3%) receiving anti-diabetic medication; and 38 (20.7%) had hypercholesterolemia, with 2 (1.1%) receiving cholesterol-lowering agents. We found that male sex (χ2=5.359, p=0.021), depressed or mixed state versus manic state (χ2=4.302, p=0.038), and duration of illness (t=2.756, p=0.006) were significantly associated with obesity. Older age (t=3.668, p<0.001), later age of disease onset (t=2.271, p=0.024), and lower level of educational attainment (β=-0.531, p=0.001) were associated with hyperglycemia.ConclusionOur finding that metabolic abnormalities are prevalent when initiating acute pharmacological treatment in bipolar I patients indicates that these factors should be integrated into treatment plans at the onset of disease management. |
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Keywords: | Bipolar disorder Hypercholesterolemia Hyperglycemia Obesity |
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