An automated method for studying exploratory and stereotyped behaviour in rats |
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Authors: | Roger O. A. Makanjuola Graham Hill Ian Maben Ronald C. Dow George W. Ashcroft |
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Affiliation: | (1) MRC Brain Metabolism Unit, University Department of Pharmacology, 1 George Square, EH8 9JZ Edinburgh, U.K. |
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Abstract: | A technique is described for studying exploratory as well as stereotyped behaviour in rats using an automated hole-board. Both visual and automated recordings can be employed using the technique. Hole dipping is monitored automatically using an infra-red detector system. Repetitive patterns of hole-dipping are used as parameters of stereotyped behaviour while the more random patterns of hole-dipping are used as parameters of exploration.There was a high significant correlation between the records of hole-dipping behaviour as recorded visually and automatically. There was also a high significant correlation between the measures of repetitiveness/randomness of hole-dipping behaviour from automatic and visual recordings. The pattern and levels of hole-dipping conformed with expectations both as regards changes with time and with increasing doses of dl-amphetamine. |
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Keywords: | Rat Exploratory behaviour Stereotyped behaviour Hole-board dl-Amphetamine |
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