Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets |
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Authors: | Ping Jin Ena Wang Maurizio Provenzano Sara Deola Silvia Selleri Jiaqiang Ren Sonia Voiculescu David Stroncek Monica C Panelli Francesco M Marincola |
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Institution: | (1) Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, 20892 Bethesda, Maryland, USA;(2) Immune Oncology Section, Department of Surgery, University Hospital ZLF, 4031, Hebelstrasse 20, Basel, Switzerland |
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Abstract: | Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation
of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among
immune cells which sways the effects of IL-2 according to the experimental or clinical condition tested. Recombinant IL-2
(rIL-2) stimulation of peripheral blood mononuclear cells (PBMC) from 47 donors of different genetic background induced generalized
T cell activation and anti-apoptotic effects. Most effects were dependent upon interactions among immune cells. Specialized
functions of CD4 and CD8 T cells were less dependent upon and often dampened by the presence of other PBMC populations. In
particular, cytotoxic T cell effector function was variably affected with a component strictly dependent upon the direct stimulation
of CD8 T cells in the absence of other PBMC. This observation may provide a roadmap for the interpretation of the discrepant
biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities. |
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