Neuropsychological performance and seizure-related risk factors in patients with temporal lobe epilepsy: a retrospective cross-sectional study |
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| Authors: | Wang Wei-Han Liou Horng-Huei Chen Chih-Chuan Chiu Ming-Jang Chen Ta-Fu Cheng Ting-Wen Hua Mau-Sun |
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| Institution: | a Department of Psychology, National Taiwan University, Taipei, Taiwanb Department of Neurology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwanc Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwand Neurobiology and Cognitive Science Center, National Taiwan University, Taipei, Taiwan |
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| Abstract: | The aim of this study was to identify the neuropsychological features in patients with temporal lobe epilepsy (TLE) and their correlation with seizure-related variables. For this purpose, we carried out a retrospective analysis of data from 65 patients with TLE who had undergone a comprehensive neuropsychological assessment. The results suggest that the majority of patients with TLE were impaired in more than one cognitive domain, and among these patients, the mean proportions with defective semantic memory, language, motor/psychomotor speed, verbal episodic memory, and executive function were > 50% each. Moreover, age at seizure onset was the strongest predictor of general intellectual impairment, and number of antiepileptic drugs and seizure frequency could significantly predict deficits in verbal memory, language, and psychomotor speed. However, epilepsy duration was a less potent predictor of cognitive deficit than has been reported in cross-sectional studies. |
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| Keywords: | Temporal lobe epilepsy Seizures Neuropsychological assessment Cognitive function |
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