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Clinical Impact of t(14;18) in Diffuse Large B-cell Lymphoma |
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| Authors: | Hong-wei Zhang # Niu-liang Cheng Zhen-wen Chen Jin-fen Wang Su-hong Li Wei Bai |
| Affiliation: | Hong-wei Zhang1,#,Niu-liang Cheng1*,Zhen-wen Chen2,Jin-fen Wang3,Su-hong Li3,Wei Bai3 1Department of Biochemistry and Molecular Biology,Shanxi Medical University,Taiyuan 030013,China,2Department of Pathology,Fen Yang College of Shanxi Medical University,Fenyang,3Department of Pathology,Shanxi Province Tumor Hospital,Taiyuan,China Department of hematology |
| Abstract: | Objective: Recent studies have suggested that t(14;18) is present in a significant proportion of diffuse large B-cell lymphomas (DLBCLs). However, the prognostic significance of this translocation and its relationship with BCL-2 protein expression remains controversial. Our study aimed to investigate the predictive power of t(14;18) and BCL-2 protein expression in the prognosis of DLBCLs. Methods: Biopsy specimens from 106 DLBCLs were analyzed using interphase fluorescence in situ hybridization (FISH). Immu... |
| Keywords: | Chromosome translocation t(14 18) FISH Survival analysis Diffuse large B-cell lymphoma |
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