软组织肿瘤MR灌注成像与肿瘤微血管生成的关系

目的:探讨MR灌注成像评价活体内软组织肿瘤微血管生成的临床价值。材料和方法:采用GRE-EPI-T2*W I序列MR灌注成像研究27例软组织肿瘤(良性12例,恶性15例),获得肿瘤的各灌注参数BV、MTT、BF及MSD、MSI;采用SP免疫组化法测量VEGF和MVD。结果:恶性肿瘤的VEGF、MVD和BV、BF、MSD值均明显高于良性肿瘤(P<0.05)。良、恶性软组织肿瘤的BV、BF、MSD与MVD间均存在显著正相关(r=0.642、0.597、0.618;r=0.599、0.685、0.624);恶性软组织肿瘤BV、BF、MSD与VEGF间有显著正相关(r=0.594、0.547、0.572)。结论:MR灌注参数BV、BF、MSD能反映活体内软组织肿瘤微血管生成及分布情况,为临床治疗和预后提供前瞻性的病理学和病理生理学信息。

Correlation of VEGF and MVD with MR-PWI in Soft Tissue Tumor

Purpose: To explroe the clinical value of angiognesis of soft tissue tumor in vivo evaluated by MR PWI.Materials and Methods: Twenty-seven patients with soft tissue tumors,including 12 cases of benign tumors and 15 cases of malignant tumors,were studied by using GRE-EPI-T2~*WR PWI technique.The perfusion parameters including blood volume(BV),mean transit time(MTT),blood flux(BF),maximal slope descending(MSD),and maximal slope increasing(MSI) can be obtained.The VEGF and MVD were measured by SP immunohistochemical staining method.Results: The VEGF,MVD,BV,BF and MSD of malignant tumors were obviously higher than that of benign's(P<0.05).There were significantly positive correlation between BV,BF,MSD and MVD for both benign and malignant tumors(r=0.594,0.547,0.572).Conclusion: The MR perfusion parameters such as BV,BF and MVD may reflect angiogenesis and distribution of soft tissue tumor in vivo,and can provide prospective pathologic and pathophysiologic informations for clinical treatment and prognosis.