老年冠状动脉病变程度与血清热休克蛋白60的相关性研究

目的研究血清热休克蛋白60(HSP60)与老年冠状动脉病变程度的相关性。方法因胸痛入院行冠状动脉造影的老年患者91例(冠心病组)和健康体检者72例(对照组),检测血清HSP60水平。标准Judkins法行冠状动脉造影术。其中49例行经皮冠状动脉介入治疗(PCI)。冠心病组患者根据冠状动脉造影和HSP60水平进行亚组比较。结果冠心病组患者与对照组血清HSP60水平间差异有显著性意义(P<0.01)。单支病变、双支病变、3支病变组患者与对照组血清HSP60差异均有显著性意义(P<0.01)。不同病变组间患者(除双支与3支病变间)血清HSP60两两比较差异均有显著性意义(P<0.01)。血清HSP60水平与PCI术中使用球囊数、球囊扩张次数、最大球囊压力呈正相关,差异有显著性意义。血清HSP60高水平组使用球囊数、球囊扩张次数、最大球囊压力、使用支架数均大于低水平组(P<0.05)。结论冠心病患者血清HSP60水平随着冠状动脉病变程度的加重而增高,检测血清HSP60水平将有助于冠心病的诊断及了解冠状动脉病变严重程度。

The correlation between serum HSP60 levels and the severity of coronary lesions of the aged

Objective To investigate the relationship between serum HSP60 levels and the severity of coronary lesions of the aged.Methods The venous blood samples were obtained from 91 patients(CHD group),who would undergo coronary angiography due to chest pain,and 72 healthy subjects.The serum HSP60 levels were determined by ELISA.Coronary angiography was done by means of standard method of Judkins.Forty-nine patients underwent percutaneous transluminal coronary intervention.Results The serum HSP60 levels of CHD group were significantly different from those of the healthy subjects(P<0.01).The serum HSP60 levels were significantly different between single-vessel disease,duple-vessel disease,triple-vessel disease except the difference between duple-and triple-vessel disease.The serum HSP60 levels were positively correlated with the number of balloons used,frequency of balloon dilation and the maximal pressure of balloon dilation in the PCI.Meanwhile,the numbers of balloons and stents used,frequency of balloon dilation,and the maximal pressure of balloon dilation in the highest HSP60 quartile group were higher than those in the lowest quartile group(P<0.05).Conclusion The serum HSP60 levels of the aged with coronary lesions were elevated with increasing severity of coronary lesions.The detection of serum HSP60 levels contributes to the diagnosis of CHD and decision of the severity of coronary lesions.