十二指肠间质瘤临床、内镜及病理特点分析

目的探讨十二指肠间质瘤临床、内镜及病理特点。方法回顾性分析经手术和病理确诊的15例十二指肠间质瘤患者的临床、内镜及病理资料。结果以黑便伴贫血为主要表现12例，间断腹痛1例，腹胀1例，腹部肿物1例。病灶位于降部10例，水平段4例，球部1例。病理学资料肿瘤直径2～15cm，平均6．1cm。组织病理检查，梭形细胞型9例，上皮样细胞型4例，混合型2例。CD117和CD34阳性表达率分别为86．6％和53．3％。病理诊断良性间质瘤5例，恶性8例，潜在恶性2例。结论十二指肠间质瘤临床及内镜下缺乏特异性表现，内镜下活检阳性率低，诊断依赖病理及免疫组化。

Analysis for clinical, endoscopi and-pathologic characteristics Of duodenal gastrointestinal stromal tumors

Objective To investigate the clinical characteristics,the endoscopic features,and patholog- ic morphology of duodenal gastrointestinal strnmal tumors(GISTs). Methods The clinical data of 15 GIST pa- tients were retrospectively analyzed. Results Common symptoms of GISTs were non-specific, included digestive tract hemorrhage and anemia(12/15) ,abdominal pain(1/15) ,abdominal masses(1/15) ,fullness(1/15). The lesions of duodenal GISTs mainly located in the descending duodenum (10/15) , in the horizontal part(4/15), and the bulb (1/15). The diameters of the masses ranged from 2 cm to 15 cm with an average of 6. 1 cm. Histio- pathologicaly,the types of tumors were classified as spindle cells tumors(9/15)and epithelioid cells tumors(4/ 15) ,and mixed cells tumors(2/15). The immunohistochemical results of GISTs showed that the positive rates of CD117 was 86. 6% , CD34 was 53.3%. 5 cases were benign. 2 cases were potentially malignant and 8 cases were malignant. Conclusion GISTs has no specific clinical and endoscopic feature. Final diagnosis should be based on pathology and immunohistochemics.