辛伐他汀对高脂血症患者内皮功能障碍的干预作用及其与碱性成纤维细胞生长因子的关系

目的 研究辛伐他汀对高脂血症患者血管内皮功能障碍的干预作用及其与血清碱性成纤维细胞生长因子的关系.方法 将54例高脂血症患者按血脂水平随机分为辛伐他汀组(28例,辛伐他汀20 mg/d,8周)和高.脂对照组(26例),另设正常对照组(29例,正常健康受试者).应用彩色多谱勒超声诊断仪测量受试者肱动脉血流介导的舒张功能,评价血管内皮功能的变化.应用酶联免疫吸附双抗体夹心法和硝酸酶还原法检测受试者血清碱性成纤维细胞生长因子和一氧化氮的含量,评价一氧化氮及碱性成纤维细胞生长因子与血管内皮功能障碍的关系.常规检测血清总胆固醇、甘油三酯、低密度脂蛋白及高密度脂蛋白的浓度.结果 8周后,辛伐他汀组与高脂对照组相比肱动脉血流介导的舒张功能明显改善(P<0.05),血清一氧化氮和血清碱性成纤维细胞生长因子含量升高(P<0.05),血清总胆固醇、甘油三酯和低密度脂蛋白浓度明显下降(P<0.01),而高密度脂蛋白浓度明显升高(P<0.01).结论 辛伐他汀可增加血清碱性成纤维细胞生长因子含量,提高一氧化氮含量,改善高脂血症患者血管内皮功能障碍,其作用机制与降低血清总胆固醇、甘油三酯和低密度脂蛋白的浓度有一定关系.

Effects of Simvastatin on Vascular Endothelial Function in Patients with Hyperlipidemia and Its Relationship to Basic Fibroblast Growth Factor

Aim To investigate the effects of simvastatin therapy on vascular endothelial function in patients with hyperlipidemia and its relationship to basic fibroblast growth factor.Methods 54 patients with hyperlipidemia were divided into two groups: simvastatin therapy group (28 patients, simvastatin 20mg daily for 8 weeks) and hyperlipidemia control group (26 patients). 29 normal healthy subjects were examined as the normal control group. The flow-mediated dilatation of brachial artery can be evaluated using high resolution ultrasound assessment of changes in the brachial artery diameter of subjects. The content of serum basic fibroblast growth factor and nitric oxide were detected by using the enzyme-linked immuno sorhent assay and enzyme reduction of nitrate, respectively. Total cholesterol, triglyceride, low density lipeprotein and high density lipeprotein for each group were measured by routine ways. Results This study showed that the percentage of flow-mediated dilatation increased and the content of serum nitric oxide and basic fibroblast growth factor were enhanced more significantly in simvastatin therapy group than that of hyperlipidemia control group (P <0.05). Compared with the hyperlipidemia control group, total cholesterol, triglyceride and low density lipeprotein decreased and high density lipeprotein increased in simvastatin therapy group (P <0.01).Conclusion Simvastatin can increase the content of serum basic fibroblast growth factor and nitric oxide, improve endothelial function of patients with hyperlipidemia. The effects of simvastatin therapy on improving vascular endothelial function might mainly relate to the decrease in the concentration of blood lipids.