降钙素原、超敏C反应蛋白及白细胞计数在肺内细菌感染性疾病中的临床应用

目的：探讨降钙素原（procalcitonin，PCT）、超敏c反应蛋白（highsensitive C-reactiveprotein，hs-CRP）及白细胞（WBC）计数在肺内细菌感染性疾病中的诊断价值。方法：将221例肺内感染患者根据病原学和血清学诊断结果分为细菌感染组（73例），病毒感染组（47例），支原体感染组（45例），真菌感染组（56例），另选择健康体检者62例作为阴性对照组，分剐检测患者血清中PCT、hs—CRP、WBC和中性粒细胞（neutrophil，Neu）的值，比较各项指标组间有无差异，根据受试者工作特征（receiver operating characteristic，ROC）曲线，确定各项指标在肺内细菌感染性疾病中的诊断价值。结果：在肺内细菌感染性疾病中的PCT、hs—CRP、WBC、Neu的ROC曲线下面积（area under the ROC curve，AUC）分别为0．979、0．789、0．691、0．631。结论：PCT、hs—CRP和WBC对于肺内细菌感染均有一定的诊断价值，但PCT是肺内细菌感染诊断的准确性较好的指标，并可用于评估感染的严重程度。

Value of Procalcitonin, High Sensitive C-reactive Protein and WBC in Patients with Bacterial Infection

Objective： To study the diagnostic value of procalcitonin （PCT）, high sensitive C-reactive protein （hs-CRP）, WBC in patients with lung bacterial infection. Methods： A sample of 221 patients with lung bacterial infection was divided into four groups, including bacterial infection （73 patients）, virus infection （47 patients）, mycoplasma infection （45 patients）, fungus in- fection （56 patients） according to the results of pathogen and serum. And 62 healthy volunteers was selected as negative control. PCT, hs-CRP, WBC, neutrophil （Neu） were measured respectively and the results were statistically analyzed. The receiver operat- ing characteristic （ROC） curve was used to evaluate the value of PCT, hs-CRP, WBC and Neu. Results： The area under the ROC curve （AUC） of PCT, hs-CRP, WBC, Neu were 0.979, 0.789, 0.691, 0.631respectively. Conclusions： PCT, hs-CRP, WBC and Neu had some value to diagnosis lung bacterial infection. But PCT is a better marker whether there is bacterial infection. The level of PCT can evaluate the severity of bacterial infection.