氟替卡松、孟鲁司特对小儿毛细支气管炎后喘息的疗效观察

目的观察氟替卡松、孟鲁司特对毛细支气管炎后喘息的影响，探讨不同干预措施的效果。方法收集2007年11月至2008年1月我院门诊及住院诊治的小儿毛细支气管炎101例，痊愈后随机分成3组：氟替卡松组28例，给予氟替卡松125ug，吸入，早晚各一次，1个月后改为1吸，每晚一次，共3个月；顺尔宁组24例，予顺尔宁4mg每晚一次，口服3个月；对照组49例，不给干预措施。对所有病例随访6个月，观察各组患儿在此期间出现喘息的人数，喘息次数，以及治疗费用情况。结果氟替卡松组和孟鲁司特组患儿喘息人数，喘息次数与对照组比较均有统计学意义（P〈0．05），两组间比较没有统计学意义；就每月治疗费用来看，氟替卡松组明显低于后两组（P〈0．01），而后两组间差异无统计学意义（P〉0．05）。结论氟替卡松、孟鲁司特均能显著降低毛细支气管炎患儿喘息发生率，并能显著减少喘息患儿的喘息次数。两种措施对毛细支气管炎日后喘息有一定的预防疗效。氟替卡松价格低廉；孟鲁司特使用简单，方便。

Effect of Fluticasone and Montelukast on Preventing Wheezing in Postbronchiolitis Children

Objective To observe effect of fluticasone and montelukast on preventing wheezing in postbronchiolitis children,and to explore the effect of different interventions.Methods 101 children with bronchiolitis after recovery were randomly divided into three groups:28 cases inhaled fluticasone 125 ug twice a day(group A),then once a month later.22 cases were given montelukast 4 mg per night(group B).While the 49 cases with no interference(group C).All children were followed up for 6 months.Results 1.The number of...