B prolymphocytic leukemia cell lines: phenotype and response to B cell differentiation factor |
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| Authors: | H Zola V Furness A Nikoloutsopoulos J Bradley J V Melo D Catovsky |
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| Affiliation: | Department of Clinical Immunology, Flinders Medical Centre, Bedford Park, South Australia. |
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| Abstract: | Three recently-derived cell lines of prolymphocytic leukemia origin were studied. The phenotype of the cells, analysed in terms of expression of immunoglobulin and other B cell maturation markers, indicates that the cells are mature B lymphocytes close to the plasma cell stage of differentiation. All three cell lines secrete IgM, and two of the three lines respond to B cell differentiation factor with an increased secretion of IgM. |
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