原发性双侧乳腺癌的预后分析

目的分析影响双侧乳腺癌患者生存率的预后因素.方法对18例经病理组织学证实的原发性双侧乳腺癌患者进行回顾性分析.其中同时发生3例(16.7%);先后发生15例(83.3%),均接受手术、放疗、化疗等综合治疗.分析原发性肿瘤临床T分期、腋下淋巴结的转移、月经情况及两侧乳腺癌发生的间隔时间与患者生存率的关系.结果原发性肿瘤临床T分期、腋下淋巴结的转移及两侧乳腺癌发生的间隔时间为患者的主要预后因素.结论原发性双侧乳腺癌患者的原发灶大小、淋巴结浸润及两侧癌发生的间隔时间与患者的预后有显著关系;第二原发乳腺癌患者的早期发现,早期治疗可提高生存率.

Prognostic factors in bilateral primary breast cancer

Objective To study the determining prognostic factors that affect the survival of patients with bilateral primary breast cancer. Methods Eighteen women with bilateral primary breast cancer were analyzed. 3(16.7%) of which presented simultaneous bilateral tumors. 15(83.3%) developed bilateral primary breast cancers at intervals. All of them were treated with surgery, radiation treatment and chemotherapy. Analysis of high risk factors of breast cancer and possible relation to survival was carried out. Results The tumor size, the number of involved axillary nodes and the time interval between two cancers were significantly correlated with survival rate. Conclusion The size of tumor, the number of involved axillary nodes and the time interval between two cancers were major prognostic factors. The early diagnosis and treatment of the second primary breast cancer are the keys to long survival rate of bilateral breast cancer.