Histopathology of mixed anaerobic intraabdominal infection in mice |
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Authors: | R E McCallum M D Rohrer R Urbaschek Prof Dr B Urbaschek |
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Institution: | (1) Department of Microbiology and Immunology, College of Medicine, The University of Oklahoma at Oklahoma City Health Sciences Center, Oklahoma City, OK, USA;(2) Department of Oral Pathology, College of Dentistry, The University of Oklahoma at Oklahoma City Health Sciences Center, Oklahoma City, OK, USA;(3) Abteilung für Immunologie und Serologie am Institut für Hygiene und Med. Mikrobiologie der Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany |
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Abstract: | Summary This study characterized acute peritonitis and chronic abscess formation resulting from experimental mixed anaerobic infection withBacteroides melaninogenicus andFusobacterium necrophorum. At intervals after infection liver and spleen samples were obtained, fixed, and processed for histological examination. An acute to chronic infection progressed in mice infected with this mixture of anaerobic bacteria, whereas, no infection resulted when either organism was injected alone. Acute inflammatory cell infiltrates were noted in tissue samples at 12 h postinfection. Small, discrete areas of liver cell necrosis with neutrophilic infiltrates were observed as early as 24 h. By 48 h after infection the liver parenchyma was infiltrated with both acute and chronic inflammatory cells, with moderate to severe hepatocyte degeneration recognized at 72 h. Large intrahepatic abscesses were present in the subphrenic (upper lobe) area 2 to 6 weeks after experimental infection. |
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Keywords: | Intrahepatic abscesses Peritonitis Bacteroides melaninogenicus Fusobacterium necrophorum Histopathology of mixed anaerobic infections |
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