|
|||||
|
|
| 蛇床子素对小鼠实验性肝损伤的保护作用 | |
| 引用本文： | 刘建新,周俐,周青,杨庆春,张文平. 蛇床子素对小鼠实验性肝损伤的保护作用[J]. 中药药理与临床, 2006, 22(2): 21-22 |
| 作者姓名： | 刘建新 周俐 周青 杨庆春 张文平 |
| 作者单位： | 1. 赣南医学院药理教研室,赣州,341000 2. 赣南医学院机能实验室 3. 赣南医学院病理教研室 |
| 摘 要： | 目的:探讨蛇床子素对小鼠CCl4肝损伤的保护作用。方法:采用CCl4小鼠急性肝损伤模型,测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)活性、肝组织MDA含量,并观察肝组织病理变化。结果:蛇床子素能保护CCl4所致小鼠肝损伤,表现为血清ALT、AST活力和肝脏MDA含量下降,同时其肝脏病变较模型组为轻。结论:蛇床子素对CCl4所致小鼠肝损伤具有保护作用。 |
| 关 键 词： | 蛇床子素 CCl4 保肝作用 |
Protective effect of osthole on experimental liver injury in mice |
|
| Liu Jianxin,Zhou Li,Zhou Qing,Yang Qinchun,Zhang Wenping. Protective effect of osthole on experimental liver injury in mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2006, 22(2): 21-22 | |
| Authors: | Liu Jianxin Zhou Li Zhou Qing Yang Qinchun Zhang Wenping |
| Affiliation: | Departmcent of Pharmmacology, Gannan Medical College, Ganzhou 341000 |
| Abstract: | Objective: To investigate the protective effect of osthole against carbon tetrachloride(CCl_4)-induced hepatotoxicity in mice. Methods: The experimental liver injury was induced by CCl_4 in mice. The serum alanine aminotransferase (ALT) and aspartate aminotransferase(AST) and liver malondialdehyde (MDA) were determined . And the pathological examination of liver was performed . Results: Osthole significantly decreased serum ALT, AST activities and liver MDA content .And the liver lobule were ameliorated obviously. Conclusion: Osthole can protect against CCl_4-induced hepatotoxicity in mice. |
| Keywords: | osthole CCl_4 hepatic-protection |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |