| EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM |
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| 引用本文： | 李箭,汪钟. EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J]. 中国医学科学杂志(英文版), 1990, 0(1) |
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| 作者姓名： | 李箭 汪钟 |
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| 作者单位： | PUMC Student.，Institute of Basic Medical Sciences CAMS，Beijing |
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| 摘 要： | ![]()
The effects of nimodipine on platelet aggregation and arachidonic acid(AA)metabolismwere studied in order to explore its effect on patients with thrombosis or cardiovas-cular disease.The results indicate that nimodipine(50-350μmol/L)significantly inhibitsplatelet aggregation induced by ADP,AA,and ionophore A23187 in a dose dependentmanner.The inhibitory effects induced by ionophore A23187 could be partially antagonizedby calcium(1 mmol/L).When the substrate was AA and the enzyme was supplied bypig lung microsomes,nimodipine(50-400μmol/L)significantly reduced the generation ofTXB_2 and 6-keto-PGF_(1a) in parallel.When the substrate was prostaglandin endoperoxide,however,the levels of TXB_2 and 6-keto-PGF_(1a)were not significantly altered in the sameconcentration range.The results suggest that nimodipine is a cyclooxygenase inhibitor,andits ability to inhibit platelet aggregation is related to its calcium blocking effect.
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| 关 键 词： | nimodipine platelet aggregation TXB_2 6-keto-PGF_(1α) cyclooxygenase |
EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM |
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| Li Jian,Wang Zhong Institute of Basic Medical Sciences,CAMS,Beijing PUMC Student.. EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J]. Chinese medical sciences journal, 1990, 0(1) |
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| Authors: | Li Jian Wang Zhong Institute of Basic Medical Sciences CAMS Beijing PUMC Student. |
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| Abstract: | ![]()
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