|
|||||
|
|
| 尼美舒利缓释微丸胶囊的制备及体外溶出度测定 | |
| 引用本文： | 李春花,王丽萍,蔡浩,周晓煜,张莉萍. 尼美舒利缓释微丸胶囊的制备及体外溶出度测定[J]. 中国药事, 2005, 19(5): 294-296 |
| 作者姓名： | 李春花 王丽萍 蔡浩 周晓煜 张莉萍 |
| 作者单位： | 1. 河北医科大学中医学院,石家庄,050091 2. 保定市第一医院 3. 河北省人才交流中心 |
| 摘 要： | 制备尼美舒利缓释微丸胶囊及测定体外溶出度.采用正交试验法研究缓释微丸的包衣处方,以成分溶出百分率为考察指标,20%的乙基纤维素(EC)为包衣材料,8%的聚乙二醇(PEG1000)醇溶液为致孔剂,枸橼酸三乙酯(TES)为增塑剂,包衣液的用量使微丸增重2%.本品平均累积溶出度与时间在1～8小时内呈良好的线性关系Q=13.14t-7.57(r=0.9905),可持续释药8h.本处方工艺合理,所制剂型达到缓释目的. |
| 关 键 词： | 尼美舒利 缓释微丸 制备 体外溶出度 |
| 文章编号： | 1002-7777(2005)05-0294-03 |
Preparation and in vitro Dissolution Research of Nimesulide Sustained Release Pellet Capsules |
|
| Li Chunhua,Wang Liping,CAI Hao,Zhou Xiaoyu,Zhang Liping. Preparation and in vitro Dissolution Research of Nimesulide Sustained Release Pellet Capsules[J]. Chinese Pharmaceutical Affairs, 2005, 19(5): 294-296 | |
| Authors: | Li Chunhua Wang Liping CAI Hao Zhou Xiaoyu Zhang Liping |
| Abstract: | Coating formula of Nimesulide sustained release pellet capsules and the dissolution in vitro were tested using orthogonal design methods. Percentages of dissolution were set as observation parameters. 20% EC was used as coating material, 8% PEG1000 as matrix and TES as hollow agent. The coating liquid increased the weight of pellets by 2%. The average accumulate dissolution showed a good linear range within 1st to 8th hr. The equation was Q=13.14t-7.57(r=0.9905). The release could sustain 8 hours. |
| Keywords: | nimesulide sustained release pellet capsules preparation dissolution in vitro |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |