Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome |
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Authors: | Selahattin Akyol Mustafa ??rtük Ahmet Oytun Baykan Kemal Kiraz Abdurrezzak B?rek?i Taner ?eker Mustafa Gür Murat ?ayli |
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Institution: | IAdana Numune Training and Research Hospital, Department of Cardiology, Çukurova/Adana, Turkey.;IIAdana Numune Training and Research Hospital, Department of Pulmonology, Çukurova/Adana, Turkey.;IIIAntalya Numune Training and Research Hospital, Department of Pulmonology, Antalya, Turkey.;IVKafkas University School of Medicine, Department of Cardiology, Kars, Turkey. |
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Abstract: | OBJECTIVE:Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome.METHODS:We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI<15, (2) AHImid group: 15<AHI≤30, and (3) AHIhigh group: AHI>30.RESULTS:The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010).CONCLUSION:The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome. |
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Keywords: | Obstructive sleep apnea Apnea-hypopnea index Mean platelet volume High sensitivity C-reactive protein |
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