Phenotypic analysis of 1-B-d-arabinofuranosylcytosine deamination in patients treated with high doses and correlation with response |
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| Authors: | W Kreis M Lesser D R Budman Z Arlin L DeAngelis P Baskind E J Feldman S Akerman |
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| Institution: | (1) Department of Medicine, North Shore University Hospital and Cornell University Medical College, 300 Community Drive, 11030 Manhasset, New York, USA;(2) Department of Research, North Shore University Hospital and Cornell University Medical College, 11030 Manhasset, New York, USA;(3) New York Medical College, 10595 Valhalla, New York, USA;(4) Memorial Sloan-Kettering Cancer Center, 10021 New York, New York, USA |
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| Abstract: | Summary Two phenotypes for 1-B-d-arabinofuranosylcytosine (ara-C) deamination corresponding to a ratio of distribution for  slow (ratio,  14) vs fast (ratio, >14) deaminators of 70% 30%, have been determined on the basis of studies on plasma ratios of 1-B-d-arabinofuranosyluracil/ara-C (ara-U/ara-C) in 56 subjects treated with high-dose ara-C (3 g/m2 infused i.v. over 3 h). A positive correlation of age with the concentration of ara-U was observed. In a subgroup of 36 patients with leukemia, the ara-U/ara-C pattern was similar to that observed for all 56 subjects. In these leukemic patients, who were treated with combinations of ara-C plus other conventional agents, a tendency toward a positive response (complete response +partial response) was found for those showing low ara-U/ara-C ratios (slow deaminators). The phenotypic effect of deamination in acute leukemia needs to be evaluated prospectively.This work was supported by the Don Monti Memorial Research Foundation |
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