| 四氧嘧啶致糖尿病兔早期心功能研究 |
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| 引用本文： | 王毅,龚联舫,舒昌达,陆杰. 四氧嘧啶致糖尿病兔早期心功能研究[J]. 重庆医科大学学报, 1995, 0(4) |
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| 作者姓名： | 王毅 龚联舫 舒昌达 陆杰 |
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| 作者单位： | Dept.of medieine，the Fiist hospital |
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| 摘 要： | 本文就四氧嘧啶诱导糖尿病兔子早期（４周）与正常兔左心功能进行比较，发现糖尿病兔左室内压最大值（ｐｅａｋ），舒张末期内压（ＥＤＰ），等容收缩压（ＩＰ）、室内压波下降段最大速率（－Ｓｍａｘ），心力环（Ａｒｅａ）均显著小于正常对照组（ＩＰ、Ｓｍａｘ、Ｐ＜０．０５，Ａｒｅａ，Ｐ＜０．００５，ｐｅａｋ，Ｐ＜０．００２，ＥＤＰ，Ｐ＜０．００１）。本文结果显示糖尿病兔早期左室舒张及收缩功能均减退，可能与糖尿病代谢异常以及由此造成的心肌病变有关。
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| 关 键 词： | 四氧嘧啶；糖尿病兔；心功能 |
A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS |
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| Wang Yi,et al.. A STUDY ON CARDIAC FUNCTION IN EARLY ALLOXAN DIABETIC RABBITS[J]. Journal of Chongqing Medical University, 1995, 0(4) |
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| Authors: | Wang Yi et al. |
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| Abstract: | he early changes of cardiac function were studied in alloxan dialbetic rabbits in comparison with nomlal con-trols.After the onset of dialsetes for 4 weeks, left ventricular function indices including the peak pressure of leftventricule(Peak),the end diastolic pressure(EDP)the isovolumic contraction pressure(IP),the Peak negative -dp/dt max,(-Smax)and the area of lieart Working cycle(Area)were all significantly lower then those of normalcontirols(IP,-Smax,P < 0.005);Area(P< 0.05)EDP,P(<0.001)The results suggested that eraly decrease of leftventricular contraction and relaxation mdy be relaed to abnomal metabolism and diabetic cardiomyopathy. |
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| Keywords: | Alloxan Diabetic rabbits Cardiac function |
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