肺癌患者化疗前后CEA、NSE、SCC-Ag和CYFRA21-1的表达及意义

目的研究肺癌患者化疗前后癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、鳞状上皮细胞癌抗原（SCC-Ag）和细胞角蛋白19的可溶性片段（CYFRS21-1）的表达及其临床意义。方法选取2010年3月至2014年3月我院收治的肺癌患者68例为研究组,选取同期肺部良性疾病患者68例为对照组,采用电化学发光法测量研究组化疗前后和对照组血清中CEA、NSE、SCC-Ag和CYFRA21-1的表达水平。结果化疗前,研究组CEA为（13.21±0.72）μg/L,NSE为（14.57±0.19）μg/L,SCC-Ag为（2.73±0.01）μg/L,CYFRA21-1为（8.21±0.05）μg/L,显著高于对照组,且差异有统计学意义（t=10.123,10.089,9.959,9.714,P=0.021,0.024,0.027,0.028）;65例成功化疗者CEA为（9.34±0.32）μg/L,NSE为（9.87±0.23）μg/L,SCC-Ag为（1.31±0.01）μg/L,CYFRA21-1为（4.07±0.02）μg/L,与化疗前比较差异有统计学意义（t=9.892,10.121,8.972,9.716,P=0.027,0.019,0.031,0.029）;3例化疗失败者4种标志物显著增高,与化疗前比较差异有统计学意义（t=9.921,9.919,8.792,8.935,P=0.023,0.024,0.026,0.031）。结论肺癌患者血清中的CEA、NSE、SCC-Ag和CYFRA21-1水平化疗成功后显著降低,化疗失败则会显著升高,可用于对化疗疗效进行评价。

Expression and significance of CEA,NSE,SCC-Ag and CYFRA21-1 before and after chemotherapy in patients with lungcancer

Objective To investigate the expression and significance of carcinoembryonic antigen（CEA）,neuron specific enolase（NSE）,squamous cell carcinoma antigen（SCC-Ag）and cytokeratin 19 soluble fragment（CYFRS21-1）before and after chemotherapy in patients with lung cancer.Methods 68 cases of patients with lung cancer in March 2010 to March 2014 in our hospital were selected,as the study group,another 68 cases of patients with benign pulmonary disease were selected,as the control group,the serum levels of CEA,NSE,SCC-Ag and CYFRA21-1of the study group and the control group were measured by the electrochemical luminescence before and after chemotherapy.Results CEA of the study group before chemotherapy was（13.21±0.72）μg/L,NSE was（14.57±0.19）μg/L,SCC-Ag was（2.73±0.01）μg/L,CYFRA21-1was（8.21±0.05）μg/L,significantly higher than the control group,with statistically significant difference（t=10.123,10.089,9.959,9.714,P=0.021,0.024,0.027,0.028）;The CEA in 65 cases of patients with success chemotherapy was（9.34±0.32）μg/L,NSE was（9.87±0.23）μg/L,SCC-Ag was（1.31±0.01）μg/L,CYFRA21-1was（4.07±0.02）μg/L,when compared with before treatment the differences were statistically significant（t=9.892,10.121,8.972,9.716,P=0.027,0.019,0.031,0.029）;4kinds of markers in 3cases of patients with failure chemotherapy were significantly increased compared with before chemotherapy,the difference was statistically significant（t=9.921,9.919,8.792,8.935,P=0.023,0.024,0.026,0.031）.Conclusion The serum CEA,NSE,SCCAg and CYFRA21-1levels are significantly reduced after success of chemotherapy while they increase significantly after the failure of chemotherapy,which can make an evaluation for the chemotherapeutic effect.