| ^131 I-chTNT 诱导淋巴瘤 Raji 细胞凋亡的实验研究 |
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| 引用本文： | 孙步彤,毕林涛,干慧珠,卢振霞,马庆杰,高识,代恩勇,赵亚男,魏淑芳.^131 I-chTNT 诱导淋巴瘤 Raji 细胞凋亡的实验研究[J].中国实验诊断学,2014(9):1409-1411. |
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| 作者姓名： | 孙步彤 毕林涛 干慧珠 卢振霞 马庆杰 高识 代恩勇 赵亚男 魏淑芳 |
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| 作者单位： | 吉林大学中日联谊医院,吉林长春130033 |
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| 基金项目： | 基金项目：吉林省自然基金面上项目（201115008） |
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| 摘 要： | 目的 探讨^131 I-chTNT 对淋巴瘤细胞的抑制作用，为淋巴瘤的临床治疗提供新策略。方法 体外培养人淋巴瘤细胞 Raji 细胞系，应用^131 I-chTNT、^131 I 以及生理盐水处理淋巴瘤 Raji 细胞，FCM 技术检测细胞凋亡的变化。结果 ^131 I-chTNT 治疗组与131 I 治疗组和空白对照组相比，FCM 显示凋亡率明显增高。结论 ^131 I-chTNT 可诱导淋巴瘤细胞凋亡、抑制淋巴瘤细胞增殖。
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| 关 键 词： | 放射免疫治疗 ^131 I-chTNT B细胞淋巴瘤 |
Experimental study of 131 I-chTNT on apoptosis of lymphoma Raji cells |
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| Institution: | SUN Bu-tong ,B I Lin-tao ,GAN Hui-zhu ,et al. (China-Japan Union Hospital of Jilin University ,Changchun 130033,China) |
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| Abstract: | Objective To explore the effect on apoptosis of ^131 I-chTNT in human lymphoma Raji cells,trying to provide a new treatment strategy for Non-Hodgkins lymphoma.Methods Human lymphoma Raji cells were cultured and were divided into 3 groups,given ^131 I-chTNT,^131 I and saline,respectively.Cells were collected and measured by flow cytometry with PI staining.Results The apoptosis rates of ^131 I-chTNT,^131 I and saline group were 13.61%,1.62% and 1%,respectively.The apoptosis rate of ^131 I-chTN group is higher than other groups （P 〈0.05）.Conclusion ^131 I-chT-NT can induct Raji cells’apoptosis,and can also inhibit Raji cells’proliferation. |
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| Keywords: | Radioimmunotherapy （RIT） ^131 I-chTNT non- Hodgkins lymphoma |
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