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Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies |
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| Authors: | Erik Roelofs Sima Qamhiyeh Frank Verhaegen Dirk De Ruysscher Gheorghe Iancu Coen Rasch Gert De Meerleer Johannes Langendijk Madelon Pijls-Johannesma Philippe Lambin |
| Institution: | a Department of Radiation Oncology (MAASTRO), Maastricht University Medical Centre, The Netherlands b McGill University, Montreal, Canada c Gesellschaft für Schwerionenforschung, Darmstadt, Germany d Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA e Netherlands Cancer Institute, Amsterdam, The Netherlands f University Hospital Ghent, Belgium g University Medical Center Groningen, University of Groningen, The Netherlands |
| Abstract: | This report introduces a framework for comparing radiotherapy treatment planning in multicentric in silico clinical trials. Quality assurance, data incompatibility, transfer and storage issues, and uniform analysis of results are discussed. The solutions that are given provide a useful guide for the set-up of future multicentric planning studies or public repositories of high quality data. |
| Keywords: | Treatment planning studies In silico Radiotherapy Multicentric Clinical trial Quality assurance Public repositories Data pooling |
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