杭州市余杭区慢性淋巴丝虫病患者生命质量调查

采用欧洲五维度健康量表(EQ-5D)对杭州市余杭区慢性丝虫病患者和健康人群(对照)进行生命质量研究。结果显示,共发出调查问卷600份,有效应答550份(91.7%),其中病例组276份、对照组274份。慢性丝虫病患者EQ-5D指数得分为0.770±0.128,对照人群为0.872±0.073。慢性丝虫病患者的行动、自我照顾、日常活动、抑郁/焦虑和疼痛/不舒服等5个维度问题报告率(43.8%、22.5%、44.9%、47.8%和29.0%)显著高于对照人群(6.6%、5.8%、12.0%、20.4%和10.6%)(P<0.01),关联强度(RR)分别为6.67、3.86、3.74、2.73和2.34。表明慢性丝虫病患者的生命质量低于健康人,主要表现在行动、自我照顾和日常活动等方面。

Investigation on life quality of patients with chronic lymphatic filariasis in Yuhang district of Hangzhou

Data were collected from chronic lymphatic filariasis patients and the public in Yuhang District of Hangzhou. Health status was assessed by using EuroQol (EQ)-5D. A total of 600 questionnaires were sent and 550 (91.7%) returned (276 chronic lymphatic filariasis patients and 274 members of the public). The EQ-SD index score for patients with chronic lymphatic filariasis (0.770 +/- 0.128) were lower than the general public (0.872 +/- 0.073). In contrast to the public (6.6%, 5.8%, 12.0%, 20.4%, and 10.6%), patients reported more problems with their mobility (43.8%), self-care (22.5%), daily activities (44.9%), anxiety/depression (47.8%), and pain/discomfort (29.0%) (P < 0.01). Strength of association were 6.67, 3.86, 3.74, 2.73, and 2.34, respectively. These results indicated that chronic lymphatic filariasis shows an impact on patients' health-related quality of life. It particularly causes great problems in the dimensions of mobility, self-care, and daily activities.