| 脑型疟发生的免疫病理机制 |
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| 作者姓名： | Liu TP Fu Y Xu WY |
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| 作者单位： | 第三军医大学基础医学部病原生物学教研室; |
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| 基金项目： | 国家自然科学基金(No.30972773)~~ |
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| 摘 要： | 脑型疟(cerebral malaria)是疟疾感染的严重并发症,近年来其发生的免疫病理学机制受到极大关注。早期的研究认为,脑型疟的发生主要与感染疟原虫的红细胞和脑血管内皮细胞黏附,导致脑血管阻塞有关。然而,越来越多的证据表明,脑型疟的发生主要由疟原虫感染后引起的免疫病理反应所导致,与炎症因子的过量释放和免疫细胞在脑血管的浸润密切相关。本文就近年来脑型疟发生的免疫病理机制的研究进展作一综述。
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| 关 键 词： | 炎症因子 脑型疟 CD8 T细胞 |
Immunopathological mechanism of cerebral malaria |
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| Liu TP,Fu Y,Xu WY.Immunopathological mechanism of cerebral malaria[J].Chinese Journal of Parasitology and Parasitic Diseases,2011,29(1):64-67. |
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| Authors: | Liu Tai-ping Fu Yong Xu Wen-yue |
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| Institution: | LIU Tai-ping,FU Yong,XU Wen-yue*(Department of Pathogenic Biology,The Third Military Medcial University,Chongqing 400038,China) |
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| Abstract: | Cerebral malaria is a severe complication of malaria.Early studies suggest that cerebral malaria is re-lated to cytoadherence of parasitized red blood cells to the microvessel endothelium of brain.However,more and more evidence supported that the cause of cerebral malaria is uncontrolled inflammatory cytokines and infiltration of lymphocytes in brain microvessel.The article summarizes the research progress on immunological mechanism of cerebral malaria. |
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| Keywords: | Inflammatory cytokine Cerebral malaria CD8 T cells |
| 本文献已被 CNKI PubMed 等数据库收录！ |
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