白介素32在气道炎症反应中的研究进展

在哮喘和慢性阻塞性肺疾病中,气道炎症反应始终贯穿疾病的发生、发展及转归.目前已发现有众多细胞及因子参与气道炎症反应,而白介素32作为一种新发现的细胞因子,很多文献证明其在炎症反应中有不可取代的作用.白介素32主要存在于自然杀伤细胞、T细胞、上皮细胞及外周血的单核细胞中,在自然免疫及特殊免疫中均有重要地位.在炎症反应中,白介素32可诱导某些因子的活性,如白介素类、肿瘤坏死因子α、核因子、促分裂原活化蛋白激酶及各种趋化因子,形成炎症级联式反应,造成气道局部的炎症,甚至引起全身性炎症反应.本文对白介素32在气道炎症中的作用作一综述.

Advancement of interleukin-32 in airway inflammatory reaction

In asthma and chronic obstructive pulmonary diskase,airway inflammation reaction runs through the development and prognosis of the disease. It has been found that many cells and cytokines are involved in airway inflammation reaction. As a novel cytokine,interleukin-32 (IL-32) plays an irreplaceable role in inflammation reaction. IL-32 mainly exists in natural killer cells,T lymphocytes,epithelial cells and monocytes, plays an important role in innate immunity and specific immunity. In the inflammatory reaction,IL-32 can induce the activity of certain cytokines, such as IL, tumor necrosis factor-α, nuclear factor, mitogen-activated protein kinase and various chemotactic factors, which can form inflammation cascade reaction, result in partial airway inflammation,even systemic inflammatory reaction. This article summarizes the role of IL-32 in the airway inflammatory reaction.