Case report: successful interdisciplinary treatment of cerebrally disseminated invasive pulmonal aspergillosis in a child with acute myeloid leukemia |
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| Authors: | Kurdow Roland Boehle Arnd-Steffen Ankermann Tobias Schniewind Bodo Dohrmann Peter |
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| Affiliation: | a Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany
b Department of General Pediatrics, University Hospital of Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany |
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| Abstract: | Invasive pulmonary aspergillosis (IPA) is a life-threatening infection in immunocompromised patients. Mortality rates of cerebrally disseminated IPA approach 100%. We report on a case of a 9-year-old girl with acute myeloid leukemia, who acquired cerebrally disseminated IPA during chemotherapy-induced leukopenia. Longtime survival was achieved by left pneumonectomy and neurosurgical resection of the intracerebral lesion combined with systemic application of itraconazole and liposomal amphotericin B. A review of literature revealed 7 other cases of cerebrally disseminated IPA with survival of more than 12 months. |
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| Keywords: | Pulmonal aspergillosis Acute myeloid leukemia Cerebral aspergillosis Surgery |
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