解郁安神汤合并阿立哌唑治疗慢性精神分裂症临床观察

目的探讨解郁安神汤合并阿立哌唑治疗慢性精神分裂症的疗效和安全性。方法将100例慢性精神分裂症患者随机分为研究组（解郁安神汤合并阿立哌唑治疗）和对照组（单用阿立哌唑治疗）各50例，观察时间12周，用阳性和阴性综合征量表（PANSS）和副反应量表（TESS）评定疗效和安全性。结果治疗12周后，研究组愈显率显著高于对照组，PANSS评分较治疗前显著下降且低于同期对照组，减分速度和幅度也大于后者，但TESS评分同期比较差异无显著性。结论解郁安神汤合并阿立哌唑治疗慢性精神分裂症疗效确切，起效较快，优于单用阿立哌唑治疗，且不增加不良反应，安全性好。

Clinical Observation on Effect of Jieyu Anshen Decoction Combined with Aripiprazole in Treating Chronic Schizophrenia

Objective To explore the efficacy and safety of Jieyu Anshen Decoction (JAD) combined with aripiprazole in treating chronic schizophrenia. Methods All 100 patients with chronic schizophrenia diagnosed according to CCMD-3 criteria were equally randomly assigned to the study group (treated with JAD combined with aripiprazole) and the control group (treated with aripiprazole alone) for 12 weeks. The efficacy and safety were evaluated by Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Side Effect Scale (TESS). Results After 12 weeks of treatment, the clinical efficacy in the study group was significantly higher than that in the control group, the PANSS score in the study group was significantly decreased with a higher speed and range of decreasing, becoming lower than that in the control group at the same period. But the difference between the two groups in scores of TESS at corresponding times showed no significance. Conclusion JAD combined with aripiprazole has definite effect in treating chronic schizophrenia, shows advantages of quickly initiating effect, high safety and with no harm for increasing adverse reactions, so it is better than using aripiprazole alone.