Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders |
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| Authors: | Pae Chi-Un Yoon Soo-Jung Patkar Ashwin A Kim Jung-Jin Lee Chul Paik In-Ho |
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| Affiliation: | Department of Psychiatry, Kangnam St. Mary's Hospital, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-701, South Korea. pae@catholic.ac.kr |
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| Abstract: | Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n=61; patients with bipolar I disorder, n=80; control, n=106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders. |
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