我院63例药品不良反应报告分析

目的：了解我院药品不良反应（ADR）发生的特点及规律。方法：对我院2008年收集并上报的63例ADR报告．分别从报告人、患者性别及年龄、引发ADR的药品、给药途径、ADR涉及器官或系统及临床表现等方面进行统计分析。结果：63例ADR报告中，50～60岁患者ADR发生率最高（36．5％）；以抗肿瘤药居多（39．7％）；给药方式以静脉滴注为主（60．3％）；ADR最常见的临床表现为皮肤及其附件损害（34．8％），其次为神经系统损害（18．0％）。结论：临床应重视抗肿瘤药物引起的不良反应，合理使用抗肿瘤药，减少或避免ADR的发生。

ADR reports analysis on 63 cases in our hospital

Objective： To investigate the laws and characteristics of adverse drug reactions （ADR） occurred in our hospital. Methods： Counted and analyzed the 63 cases of ADR reports collected and reported in 2008 with the aspects of the re- porters, sex and age of patients, causing ADR drugs, routes of administration, organs, systems and clinical manifestation re- lated to ADR. Results： The incidence of ADR among the patients with the ages of 50-60 was highest （36.5%）; the incidence of antineoplastic agents causing ADR was 39.7%; the major administration route was intravenous drip （60.5%）. Among 65 cases of ADR reports, damaged to the skin and appendant was the most ADR common clinical manifestation （34.8%）, followly nervous system damaged （18.0%）. Conclusion： ADR caused by antineoplastic agents should be paid attention, and rational use of antineoplastic agents can reduce or avoid the occurrence of ADR.