| Abstract: | Summary The effect of insulin on the concentration of different glycosaminoglycan (GG) fractions was different in different segments
of aorta. Chondroitin sulphate A and heparin were increased in the aortic arch, thoracic and abdominal aorta, while chondroitin
sulphate B and C were increased only in the aortic arch and abdominal aorta. Heparin sulphare and hyaluronic acid were increased
only in the abdominal aorta. In the liver, significant increases occurred in all GG fractions. All enzymes studied which are
involved in the biosynthesis of GG precursors,i.e. glucosaminphosphate isomerase, UDP glucose dehydrogenase and glucose-1-phosphate uridylyltransferase, were increased in the
animals of the insulin group, while all enzymes involved in the degradation of GG,i.e. hyalurono glucosidase, β-glucuronidase, β-glucosaminidase, arylsulphatase and cathepsin D, were decreased. Concentration
of hepatic PAPS, activity of the sulphate-activating system and sulphotransferase increased on administration of insulin. |
